Forskolin is a natural compound extracted from the Coleus forskohlii plant, which belongs to the mint family. It has been used in traditional Indian medicine (Ayurveda) for centuries and is currently being studied for its potential benefits in various health areas.
It was first identified and isolated in 1974 by Dr. S. R. M. Rao’s team, an Indian researcher studying the bioactive compounds of traditional plants. His studies revealed that this compound had the ability to activate adenylate cyclase, leading to extensive research on its potential applications in medicine and aesthetics.
Forskolin extraction method
The extraction of forskolin from the Coleus forskohlii plant begins with the collection of its roots, which contain the highest concentration of the active ingredient. These roots undergo a drying process and are then ground into a fine powder, facilitating the extraction of the bioactive compounds.
Next, an appropriate solvent, such as ethanol, methanol, or water, is used to dissolve and extract forskolin. In more advanced methods, supercritical CO₂ extraction can be used, which allows for obtaining a purer extract without unwanted chemical residues.
Subsequently, the obtained solution undergoes purification processes, such as column chromatography or crystallization, in order to isolate forskolin in its most concentrated form.
Finally, the extract is standardized to ensure a uniform forskolin content, typically between 10% and 20%, thus ensuring its effectiveness in medical and aesthetic applications.
Potential benefits of forskolin
Some studies have shown a certain reduction in body fat, but the evidence is inconclusive. It is believed that forskolin may stimulate the production of cyclic AMP (cAMP), a compound that promotes fat burning and weight loss.
It has also been studied for its potential benefits in heart failure and other heart conditions, as well as for improving lung function and relaxing the muscles of the airways.
Additionally, some studies have suggested that forskolin could increase testosterone levels, which could influence muscle mass and metabolism.
Use of forskolin in aesthetic medicine
It is used in some aesthetic products due to its ability to stimulate lipolysis (fat breakdown) and improve skin firmness. In medical-aesthetic equipment and advanced cosmetics, its use is typically focused on the following effects:
- Localized fat reduction
- Forskolin activates adenylate cyclase, an enzyme that increases cyclic AMP (cAMP) levels in cells.
- This process stimulates lipolysis, which is the breakdown of triglycerides into free fatty acids, which can then be eliminated by the metabolism.
- It is used in treatments to shape the body and reduce fat in specific areas without the need for invasive procedures.
- Improved circulation and lymphatic drainage
- By promoting the dilation of blood vessels, it helps improve blood and lymphatic flow, which can reduce fluid retention and enhance the appearance of the skin.
- This is useful in treatments for cellulite and tired legs.
- Firming and toning effect
- Various studies suggest that it may stimulate collagen production and improve skin elasticity.
- It is used in firming treatments to combat sagging in the abdomen, thighs, and arms.
- Booster of other active ingredients
- It is often combined with other ingredients such as caffeine, carnitine, and retinol, as the increase in cAMP enhances the action of these compounds on the skin.
- This makes it attractive for formulations of slimming creams, needle-free mesotherapy, and aesthetic technologies such as radiofrequency or cavitation.
At Sisneo, we use Forskolin in the Mesoactives 3D Sculptor product for transdermal electroporation.
Commitment to quality
This text about forskolin has been written by professional copywriters. In addition, we have relied on experts in medicine, engineering and aesthetics as a source of information, as well as specific studies to maintain the quality of what we publish.
At Sisneo Bioscience we are committed to publish truthful and contrasted information. And to update or correct it as soon as new knowledge becomes available.
Among others, we have used the following sources:
- Chen JY, Peng SY, Cheng YH, Lee IT, Yu YH. Effect of Forskolin on Body Weight, Glucose Metabolism and Adipocyte Size of Diet-Induced Obesity in Mice. Animals (Basel). 2021 Mar 1;11(3):645. doi: 10.3390/ani11030645. PMID: 33804418; PMCID: PMC8000574.
- Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 2005 Aug;13(8):1335-43. doi: 10.1038/oby.2005.162. PMID: 16129715.