What is Hederagenin?

Hederagenin is a pentacyclic triterpene of the oleanane type, found in various plant species, particularly in Hedera helix (common ivy). Its relevance in aesthetic medicine has increased in recent years due to its multifunctional bioactive profile, which includes lipolytic, anti-inflammatory, venotonic, and dermotonic properties.

These characteristics position it as an active ingredient with high potential in body contouring protocols, cellulite treatment, and improvement of skin firmness.

Mechanisms of action of Hederagenin

1. Stimulates fat burning: it promotes the release of accumulated fat from fat cells. It activates the body’s natural processes that help break down triglycerides (stored fats) and convert them into energy. This is why it is useful in treatments aimed at reducing volume and shaping the silhouette.
2. Reduces tissue inflammation: in areas affected by cellulite or fluid retention, there is often local inflammation that worsens the appearance of the skin. Hederagenin helps soothe this inflammation and decongest the tissues, which improves skin texture and reduces the feeling of heaviness.
3. Improves circulation: one of its most valued effects is its ability to activate microcirculation. By doing so, it enhances blood flow and lymphatic drainage, promoting the elimination of toxins and retained fluids. This is key in anti-cellulite and post-operative treatments.
4. Firms and tones the skin: in addition to reducing fat and fluids, this plant-based active ingredient also helps the skin appear firmer. It improves oxygenation and nourishment of the deeper layers of the skin, resulting in a smoother and healthier appearance.

Clinical applications in aesthetics

The multifunctional profile of Hederagenin makes it a strategic ally for professionals seeking effective, natural, and scientifically grounded alternatives.

• Edematous and fibrous cellulite: due to its combined lipolytic and anti-inflammatory effects.
• Localized adiposity: in mesotherapy or intradermotherapy treatments.
• Mild to moderate skin laxity: as an adjunct in firming protocols.
• Postoperative treatments: after liposuction or cryolipolysis, to accelerate edema reabsorption and facilitate tissue recovery.

Formulation and routes of administration

Hederagenin can be incorporated into various pharmaceutical forms:

• Mesotherapy: diluted in isotonic solutions for intradermal or subcutaneous injection.
• Cosmeceuticals: creams or gels for topical application with liposomal or nanotechnology delivery systems.
• Electroporation or iontophoresis: to optimize non-invasive transdermal penetration. At Sisneo, we use Hederagenin in the reducing product for the 3D Sculptor electroporation device.

It is important to highlight that its efficacy is related to the active concentration, the type of vehicle, and the route of administration, being more evident in treatments combined with devices (ultrasound, radiofrequency, vacuum therapy, etc.).

Topical use of hederagenin may cause irritation in sensitive skin, so a tolerance test is recommended beforehand. Its use is not recommended during pregnancy or in patients with active kidney diseases, due to its effects on metabolism and fluid excretion.

Elasticity

Electroporation

Fat