What is Palmitoyl Tripeptide-5?

Palmitoyl Tripeptide-5 is a synthetic peptide (three amino acids linked to palmitic acid) widely used in anti-aging cosmetics. This ingredient penetrates the deeper layers of the skin and activates the TGF-β growth factor, which is essential for the synthesis of type I and II collagen and fibronectin.

In practice, this means that it stimulates fibroblasts (collagen-producing cells) and mimics a natural reparative protein, which promotes skin regeneration and firmness. As a result, with continued use, the skin becomes smoother and more elastic, thanks to increased internal collagen and improved moisture retention.

Main cosmetic benefits

This peptide is highly valued in advanced cosmetics for its firming and anti-aging effects. Its benefits include:

• Collagen stimulation: increases collagen production in the dermis, strengthening the skin’s internal structure.
• Reduction of wrinkles and fine lines: by improving skin firmness, it visibly reduces wrinkles and crow’s feet, leaving the skin smoother.
• Improved elasticity: strengthens the dermal matrix and elasticity, making the skin feel firmer and more elastic.
• Hydration: helps retain water in the skin layers, protecting against dryness and keeping the skin plump.
• Tolerance and safety: it is considered a very safe and well-tolerated active ingredient, even for sensitive skin, allowing it to be used in various formulations without irritation.

Thanks to these anti-aging properties, Palmitoyl Tripeptide-5 is often included in advanced formulas such as firming serums and creams, tightening the skin and improving its texture. Studies have also shown that it can protect existing collagen from degradation and help even out the skin tone. Ultimately, with regular use, the skin is expected to appear firmer, more radiant, and more resilient to the passage of time.

Compatibility with aesthetic devices

One of the main advantages of Palmitoyl Tripeptide-5 is that it has no contraindications with modern non-invasive cosmetic treatments. In fact, microcurrents and radiofrequency (among other aesthetic device technologies) stimulate circulation and collagen production, while also enhancing the absorption of cosmetics applied afterward.

For example, after a microcurrent session, the skin tends to absorb serums or creams much better, so applying a product with this peptide immediately afterward can enhance its anti-aging results.

Products with Palmitoyl Tripeptide-5

This ingredient appears in many high-end anti-aging products. You can find it in:

• Anti-aging creams and serums: firming facial formulations applied during the day or night.
• Intensive treatment ampoules or vials: liquid or gel concentrates designed for a quick collagen boost.
• Firming eye contour: lightweight creams specially designed for the periorbital area, where they help reduce fine lines.
• Advanced facial masks: collagen or algae masks that contain peptides for instant firmness.
• Post-treatment products: professional gels or serums designed for use after clinical treatments (such as peels or microdermabrasion).

At Sisneo, we use Palmitoyl Tripeptide-5 in the Mesoactives product for transdermal electroporation Skin Balance. With its use, we aim to increase collagen production.

Aging

Fibroblasts

Wrinkles