Lipolytic is an adjective that describes the function of the active ingredients used in aesthetic treatments with “fat burning” properties. These produce the hydrolysis of fats giving rise to free fatty acids.


Lipolysis is the natural or artificial process of fat burning.

  • Lipids are naturally hydrolyzed by the body, causing the release of fatty acids and glycerol to meet energy needs.
  • Through the use of active ingredients, they cause the degradation of triglycerides into fatty acids and glycerol, which are eliminated naturally through the lymphatic system. These active ingredients act on cutaneous lipids. Lipolytic substances are injected into the adipose tissue to dissolve fat, improving lymphatic and blood circulation.


It is a chemical reaction produced by the body, antagonistic to lipolysis, in which fat accumulation occurs due to excessive carbohydrate consumption.

This process is carried out by synthesizing fatty acids to form triglycerides. These fatty acids are stored in adipose tissue.

Lipogenesis takes place in the liver and adipose tissue, through the storage of fat.

Active ingredients for lipolysis

Some of the lipolytic active ingredients with the best results are caffeine, Asian pennywort, hederá, fucus vesiculosus, mellilotus officianalis and Gingko Biloba.

All of them are present in Sisneo’s Skin Radiance line for transdermal electroporation.

Caffeine is an antioxidant and can penetrate the skin unaided. Asian pennywort has healing, moisturizing and antioxidant properties. Hedera and Fucus vesiculosus are also antioxidants. The latter is rich in iodine, iron and calcium.

Mellilotus offianalis is decongestant and promotes circulation. Finally, Gingko Biloba has an anti-inflammatory effect.

All these substances accelerate the lipolysis process.

Lipolytic treatments

In aesthetics, lipolytic treatments have better results if they are combined with other techniques, such as transdermal electroporation, injected mesotherapy, carboxytherapy, radiofrequency and cavitation.

It is important to note that lipolytic products are not slimming. They help fight localized fat, which is the fat that remains deposited and is difficult to eliminate even with exercise and diet.

The areas of the body where lipolytic treatments are usually performed to combat localized fat are the thighs, abdomen, upper extremities, lower buttocks and under the chin.

Laser lipolysis

Laser lipolysis is a non-invasive technique that offers fat destruction through the application of laser energy.

It works by inserting a thin, flexible cannula with fiber optics at the end. This point emits energy and melts fat.

It consists of laser emitters that are statically placed on the body. If we analyze the applicator carefully, we will see that if we believe the effectiveness of the technique, only the parts of the body below the applicator dots would be thinned.

Commitment to quality

This text on the term lipolytic has been prepared by professional editors and reviewed by Sisneo’s medical-aesthetic team. In addition, we have relied on experts in medicine, engineering and aesthetics as a source of information, as well as specific studies to maintain the quality of what we publish.

At Sisneo Bioscience we are committed to publish truthful and contrasted information. And to update or correct it as soon as new knowledge becomes available.

Among others, we have used the following references:

  • Beyene HB, Olshansky G, Giles C, Huynh K, Cinel M, Mellett NA, Smith AAT, Shaw JE, Magliano DJ, Meikle PJ. «Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study» en Metabolites. 2021 Sep 21;11(9):646. doi: 10.3390/metabo11090646. PMID: 34564462; PMCID: PMC8471381.